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Definition of affliction:

  1. The cause of continued pain of body or mind, as sickness, losses, etc.; an instance of grievous distress; a pain or grief.
  2. The state of being afflicted; a state of pain, distress, or grief.

Synonyms:

sadness, health, disorder, help, sorrow, mourning, sickness, wretchedness, ailment, heavy, cross, unhappiness, wretchedness, cross, wo, illness, infirmity, over, heartache, happy, disease, melancholy, care, disorder, sickness, visitation, tsoris, regret, cross to bear, plight, indisposition, infirmity.

Usage examples: