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Definition of anguish:

  1. Extreme pain, either of body or mind; excruciating distress.
  2. To distress with extreme pain or grief.

Synonyms:

fretfulness, overrefinement, misgiving, straining, fear, concern, solicitude, distortion, curse, pain, fretting, foreboding, bedevilment, torturing, torment, torture, harassment, spite, ail, injure, apprehension, twisting, trouble, worry, worrying, offend, hurt, disturbance, happy, study atdistress, care, dread, perplexity, woe, badgering.

Usage examples: