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Definition of bother : 1. One who, or that which, bothers; state of perplexity or annoyance; embarrassment; worry; disturbance; petty trouble; as, to be in a bother.
2. To annoy; to trouble; to worry; to perplex. See Pother.
3. To feel care or anxiety; to make or take trouble; to be troublesome.

Synonyms:

blip, issue, storm, rumpus, nudnik, hurting, terrify, feelings, call on the carpet, ache, hurry-scurry, bobbery, nuisance, disquiet, commove, stab, bugbear, worry, drag, hurly, anesthetise, dogfight, extend, tantalize, tantalise, have words, access, inconvenience, dither, hubbub, anaesthetise, reprimand, tiff, lambast, stifle, cark, shake, pother, fun, gall, zoo, whirl, annoying, can't bring yourself to do something, scratch, ride, welter, neglect, squabble, reproof, bug, retire, bring out, moil, calamity, get, anesthetize, calm, make, frighten/scare the wits out of someone, grief, tumult, uproar, menace, mystify, puzzle, put out, clatter, devil, distract, imposition, botheration, rebuke, teaser, stick, bicker, refrain, douse, frighten, rock, joke, smother, inconvenience oneself, shake up, abstain, urticate, care, sit by, squall, toss, disoblige, agitate, lambaste, stretch forth, alarm, unhinge, dismay, to-do, pandemonium, pettifoggery, let nature take its course, excoriate, persecutor, hang over, hurry, teething problems, splore, progress to, concern, fuss, kill, rough-and-tumble, headache, furor, hiccup, gnawer, amaze, gadfly, ado, hubble-bubble, tussle, pip, flurry, stupefy, nonplus, problem, do, painful sensation, scold, hoopla, discommode, anaesthetize, bawl out, fluster, stir up, rattle, raise up, scuffle, ruckus, crucify, wound, hoo-ha, reach, rag, annoyer, make no move, painfulness, baffle, nark, distress, dress down, jaw, ruffle, fray, trial, chew up, triviality, disorder, flap, release, hurly-burly, alarums and excursions, ruction, bustle, hair shirt, get to, hustle, perplex, shindy, chew out, hullabaloo, trounce, foofaraw, hold out, incommode, pain in the neck, aggro, madden, bewilder, beat, roil, twit, flummox, pest, intimidate, corroboree, take to task, rally, nettle, exsert, difficulty, suffer, coil, pound, pose, kerfuffle, dumbfound, call down, get at, glitch, dun, the thin end of the wedge, unsettle, stand by, frustration, irritant, razz, ail, stretch out, rub, remonstrate, pain in the ass, aggravator, startle, depress, pain, anxiety, drive someone mad, (just) the tip of the iceberg, gravel, pain sensation, hitch, chill, panic, stir, clutter, blather, hurt, wrinkle, omit to do something, bluster, cod, trouble oneself, helter-skelter, scare, lecture, tizzy, chide, publish, williwaw, thorn, ballyhoo, bickering, turmoil, berate, spat, furore, frustrate, hurricane, stew, devastate, row, taunt, infliction, put under

badger, bait, nag, disturb, discompose, envenom, antagonize, exasperate, grate, perturb, upset, harass, chafe, peeve, harry, enrage, torment, bedevil, inflame, needle, pester, rankle, trouble, infuriate, aggravate, exacerbate, arouse

displease, scandalize, aggrieve, jar, offend, disappoint, shock, disgust, rile, provoke, repel, anger

hassle, acerbate, pique, irk, irritate, tease, annoy, fret, vex

harassment, virulence, perturbation, inflammation, resentment, disturbance, aggravation, ire, enragement, annoyance, irritation, bedevilment, exacerbation, arousal, provocation, scorn, vexation, discomposure, petulance, indignation, exasperation

Usage examples:

• " Don't bother about that now, Ted," he said. - "I Walked in Arden", Jack Crawford.
• They don't bother around too much! - "Gentle Julia", Booth Tarkington.
• Bother the old party! - "Mrs. Wiggs of the Cabbage Patch", Alice Caldwell Hegan.