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Definition of bothersome : 1. causing irritation or annoyance; " tapping an annoying rhythm on his glass with his fork"; " aircraft noise is particularly bothersome near the airport"; " found it galling to have to ask permission"; " an irritating delay"; " nettlesome paperwork"; " a pesky mosquito"; " swarms of pestering gnats"; " a plaguey newfangled safety catch"; " a teasing and persistent thought annoyed him"; " a vexatious child"; " it is vexing to have to admit you are wrong"
2. Vexatious; causing bother; causing trouble or perplexity; troublesome.

Synonyms:

peeving, cranky, mocking, peevish, nettling, plaguy, pesky, corruptive, pathetic, plaguey, peckish, pain, vexatious, galling, pettish, dirty, scratchy, obscene, provoking, abrasive, frustrating, petulant, perversive, tetchy, techy, pestilent, pesty, fractious, rebarbative, irritative, irritable, quizzical, pestiferous, nettlesome, riling, carking, pestilential, testy, maddening

enraging, bedeviling, harassing, exasperating, perturbing, infuriating, upsetting, pestering, disturbing, exacerbating, rankling, vexing, antagonizing, grating, teasing

nasty, distasteful, obnoxious, repulsive, unpalatable, disgusting

distressful, uncomfortable, anguishing, hurtful, acute, besetting, burdensome, inflaming, wrenching, smarting, grievous, odious, irksome, oppressive, offensive, cruel, bitter, gnawing, aggravating, tormenting, torturing, troublesome, withering, biting, severe, crushing, annoying, aching, woeful, piercing, grueling, irritating, unbearable, trying, sore, painful, horrendous, arduous, miserable, throbbing, stabbing, cutting, chafing, agonizing, cramping, stinging, unpleasant, disagreeable, excruciating, harrowing, insufferable

fussy, rough, demanding, uphill, finicky, knotty, complex, strenuous, cumbersome, wearying, adverse, harsh, complicated, contrary, wearing, tight, grinding, wearisome, onerous, thorny, hard, ticklish, laborious, cantankerous, formidable, difficult, toilsome, tough, stressful, rugged, tricky

Usage examples:

• The man scratched his head, contemplating William as he might some illegible sign- post set up at an unusually bothersome cross- road. - "The Delectable Duchy", Arthur Thomas Quiller-Couch.
• Again the bothersome limitations of personality asserted themselves; and one perceived immediately that criticism, meaning by that the consistent application of any comprehensive canon of dramatic art, was out of the question. - "Famous Prima Donnas", Lewis Clinton Strang.
• Ivan Mikhailovitch is working very hard; and rehearsals are bothersome things. - "The Genius", Margaret Horton Potter.