CRICHTON-BROWNE'S SIGN

\kɹˈa͡ɪtənbɹˈa͡ʊnz sˈa͡ɪn], \kɹˈa‍ɪtənbɹˈa‍ʊnz sˈa‍ɪn], \k_ɹ_ˈaɪ_t_ə_n_b_ɹ_ˈaʊ_n_z s_ˈaɪ_n]\

Definitions of CRICHTON-BROWNE'S SIGN

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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