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Definition of defame : 1. Dishonor.
2. To charge; to accuse.
3. To harm or destroy the good fame or reputation of; to disgrace; especially, to speak evil of maliciously; to dishonor by slanderous reports; to calumniate; to asperse.
4. To render infamous; to bring into disrepute.

Synonyms:

minimize, injure, invent, vituperate, damage, maculate, taint, misuse, incriminate, maltreat, belittle, fabricate, pervert, crimes, mislead, manufacture, bend the truth, stain, prostitute, abuse, victimize, impose on _or_ oppress, make up, backbite, blur, wrong, charge, ravish, cast aspersions on, deceive, impeach, smirch, asperse, indict, molest, misspeak, ill-treat, smutch, revile, attack, law, aggrieve, cloud, lie, persecute, harm, slur, smudge, ruin, daub, ill-use, concoct, violate, criminate, upon, tear down, rail at, misemploy, corrupt

malign, dishonor, mock, shame, disgrace, embarrass, degrade, abase

defile, vilify, disapprove, denounce, reproach, chastise, admonish, deprecate, chide, blame, deride, censure, condemn, castigate, renounce, scorn, upbraid, chasten, discredit, denigrate, criticize

slander, smear, badmouth, besmirch, pillory, besmear, scandalize, libel, blacken, sully, calumniate, tarnish, traduce, stigmatize

depreciate, cast aspersion, lessen, detract, disparage, diminish, decry, discount, derogate, abrade, reduce

Usage examples:

• That in his depravity he should have stolen was bad enough; but that now, to cover his tracks, he should accuse and defame a defenceless woman is infamy! - "'Laramie;' or, The Queen of Bedlam.", Charles King.
• For those who wish to defame you will assert that I am wise, though I am not. - "Apology, Crito, and Phaedo of Socrates", Plato.
• I have done nothing to defame your character, in spite of what has passed. - "The Day of Judgment", Joseph Hocking.