Definition of despair :
1. Loss of hope; utter hopelessness; complete despondency.
2. That which is despaired of.
3. To be hopeless; to have no hope; to give up all hope or expectation; - often with of.
4. To cause to despair.
5. To give up as beyond hope or expectation; to despair of.
hopelessness (part of speech: noun)
despondency, misery, bleakness, dispiritedness, disheartenment, hopelessness, desperation, cheerlessness, heartlessness, abandonment, gloominess, downheartedness, gloom, anguish, spiritlessness, moroseness, glumness, pessimism, forlornness, depression, dejection, melancholy, discouragement
dejection (part of speech: noun)