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Definition of despair : 1. Loss of hope; utter hopelessness; complete despondency.
2. That which is despaired of.
3. To be hopeless; to have no hope; to give up all hope or expectation; - often with of.
4. To cause to despair.
5. To give up as beyond hope or expectation; to despair of.

Synonyms:

give up, despond, hope

despondency, misery, bleakness, dispiritedness, disheartenment, hopelessness, desperation, cheerlessness, heartlessness, abandonment, gloominess, downheartedness, gloom, anguish, spiritlessness, moroseness, glumness, pessimism, forlornness, depression, dejection, melancholy, discouragement

blues, sadness, ennui, sullenness, woefulness, anxiety, contemplativeness, mournfulness, plaintiveness, wistfulness, moodiness, grimness, pensiveness, dolorousness, dreariness, joylessness

Usage examples:

• Then it happened; the thing happened which was to prove both a promise and a despair. - "One Purple Hope!", Henry Hasse.
• You said: 'If I was as young as you are, I should not despair. - "The Legacy of Cain", Wilkie Collins.
• " Don't despair," he murmured. - "The Secret of the Night", Gaston Leroux.