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Definition of despair:

  1. Loss of hope; utter hopelessness; complete despondency.
  2. That which is despaired of.
  3. To be hopeless; to have no hope; to give up all hope or expectation; - often with of.
  4. To cause to despair.
  5. To give up as beyond hope or expectation; to despair of.

Synonyms:

despond, desperation, hope, give up.

Usage examples: