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Definition of despond:

  1. Despondency.
  2. To give up, the will, courage, or spirit; to be thoroughly disheartened; to lose all courage; to become dispirited or depressed; to take an unhopeful view.

Synonyms:

depression, dispiritedness, disconsolateness, gloominess, desolation, blues, dreariness, hope, glumness, forlornness, hopelessness, despair, despondency, dumps, desperation, doldrums, mournfulness, gloom, mopes, despondence, melancholy, blue devils, heartsickness, miserableness, sorrowfulness, give up, unhappiness, dejection, joylessness, oppression, dolefulness, downheartedness.

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