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Definition of difference : 1. An addition to a coat of arms to distinguish the bearings of two persons, which would otherwise be the same. See Augmentation, and Marks of cadency, under Cadency.
2. Choice; preference.
3. Disagreement in opinion; dissension; controversy; quarrel; hence, cause of dissension; matter in controversy.
4. That by which one thing differs from another; that which distinguishes or causes to differ; mark of distinction; characteristic quality; specific attribute.
5. The act of differing; the state or measure of being different or unlike; distinction; dissimilarity; unlikeness; variation; as, a difference of quality in paper; a difference in degrees of heat, or of light; what is the difference between the innocent and the guilty?
6. The quality or attribute which is added to those of the genus to constitute a species; a differentia.
7. The quantity by which one quantity differs from another, or the remainder left after subtracting the one from the other.
8. To cause to differ; to make different; to mark as different; to distinguish.

Synonyms:

loss, passing, residuum, contrariety, dispute, diversion, fight, agree, rest, agreement, balance, dissent, inharmony, discrepance, schism, faction, divagation, gap, deflection, divergency, deviance, same, discrimination, divarication, oddment, leaving, end, difference of opinion, residue, interval, difficulty, departure, engagement, heterogeneity, contradistinction, likeness, battle, expiration, unconformity, estrangement, similarity, contravention, remnant, struggle, going away, war, opposition, antithesis, dissentience, confrontation, going, exit, remainder, residual, contrariness, deflexion, release, differentiation

discord, raucousness, commotion, antagonism, friction, altercation, discordancy, hubbub, riot, disharmony, hostility, squabble, dissonance, dissension, harshness, cacophony, dissidence, enmity, warfare, row, animosity, disagreement, antipathy, feud, imbroglio, strife, collision, brawl, tension, squall, contention, hassle, clamor

inapplicability, irrelevance, alienation, detachment, extraneousness, breach, foreignness, division, disjunction, remoteness, dissociation, segregation, separation, other

deviation, uniqueness, aberration, curiosity, uncommonness, impropriety, irregularity, exception, quirkiness, funniness, singularity, derangement, incompatibility, eccentricity, abnormality, nonconformity, incongruity, outlandishness, peculiarity, strangeness, oddity, freakishness, unconventionality, anomaly, idiosyncrasy, unfamiliarity

dissimilitude, heterogeneously, aberrance, unlikeness, divergence, dissimilarity, discordance, non-uniformity, distinction, inconsistency

forte, cachet, individuality, quirk, quality, property, discriminant, particularity, specialization, definiteness, characteristic, hallmark, stamp, flavor, trait, mannerism, specialty, way, feature, figure, keynote, mark

separateness

metamorphosis, revision, transfiguration, alteration, mutation, matter, transition, change, adjustment, shift, have an effect, conversion, modification, adaptation, diversification, transposition, transformation, affect, reformation, modulation

diverseness, disaccord, multifariousness

counterpoint, conflict, disunity, distinctness, contradiction, clash, inequality, dissemblance, mismatch, variance, variation, variety, contrast, disparity, discrepancy, asymmetry, diversity

digression

Usage examples:

• " What difference does ... - "The Short Life", Francis Donovan.
• I don't see much difference: they're both of them nothing but men. - "A Woman Named Smith", Marie Conway Oemler.
• It does make a difference when you know one of them- doesn't it?.... - "Red Fleece", Will Levington Comfort.