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Definition of disadvantage : 1. Deprivation of advantage; unfavorable or prejudicial quality, condition, circumstance, or the like; that which hinders success, or causes loss or injury.
2. Loss; detriment; hindrance; prejudice to interest, fame, credit, profit, or other good.
3. To injure the interest of; to be detrimental to.

Synonyms:

disfavour, outrage, injustice, negative, mischief, defect, impairment, benefit, fault, inadequacy, failing, objection, advantage, help, bar, deficiency, hurt, harm, prejudice, liability, limitation, wrong, imperfection, weakness, difficulty, minus, problem, stumbling block, trouble, loss, disability, weak point, inconvenience, effectiveness, damage, injury, disfavor, blemish

bane, vice, depravity, malfeasance, detriment, evil, wrongness, turpitude, inadvisability, unpleasantness, badness, baseness, blackness

deprivation

brake, encumbrance, bung, barrier, handicap, impasse, bafflement, deterrent, constraint, hindrance, snag, impedance, bottleneck, delay, complication, opposition, jam, restraint, drawback, snarl, restriction, resistance, congestion, interruption, damper, impediment, mire, entanglement, hurdle, entrapment, constipation, blockade, choke, obstacle, obstruction, tangle, plug, stoppage, burden, blockage, clog, catch, block, stop, stay, frustration, drag, crimp, dam, inhibition

Usage examples:

• Nevertheless, I don't know why- unless it be that his brow is so clear and open- but he is no longer at a disadvantage beside Leo." - "Under a Charm, Vol. II. (of III) A Novel", E. Werner.
• " With the exception of the assistance they might have rendered the ships, if disabled, they were a great disadvantage," he wrote. - "Admiral Farragut", A. T. Mahan.
• She took up a woman's lot, with all its uncertainty and disadvantage; the lot of working for others. - "The Other Girls", Mrs. A. D. T. Whitney.