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Definition of disease : 1. An alteration in the state of the body or of some of its organs, interrupting or disturbing the performance of the vital functions, and causing or threatening pain and weakness; malady; affection; illness; sickness; disorder; -- applied figuratively to the mind, to the moral character and habits, to institutions, the state, etc.
2. Lack of ease; uneasiness; trouble; vexation; disquiet.
3. To deprive of ease; to disquiet; to trouble; to distress.
4. To derange the vital functions of; to afflict with disease or sickness; to disorder; - used almost exclusively in the participle diseased.

Synonyms:

insanity, visitation, plague, nervous disorder, spell, complex, distemper, pathological case, contagion, unsoundness, pathological condition, ill, epidemic, health, seizure, symptomatology, temperature, affliction, psychosomatic illness, morbidity, functional disorder

disease (part of speech: noun)

disorder, ague, handicap, complication, condition, spasm, nausea, infliction, symptom, affection, virus, apoplexy, complaint, sickness, breakdown, syndrome, bug, illness, queasiness, ailment, indisposition, attack, malaise, curse, unhealthiness, disability, fever, debility, sickliness, decrepitude, malady, collapse, infection, pestilence, infirmity, feverishness

unhealthiness (part of speech: noun)

insalubrity, pathology, contagiousness, unwholesomeness, noxiousness, deadliness, contamination, toxicity, malignancy, poisonousness

Usage examples: