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Definition of estrange : 1. To alienate the affections or confidence of; to turn from attachment to enmity or indifference.
2. To divert from its original use or purpose, or from its former possessor; to alienate.
3. To withdraw; to withhold; hence, reflexively, to keep at a distance; to cease to be familiar and friendly with.

Synonyms:

sour, love, set at odds, alien, disgruntle

distance, alienate, divorce, disunite, divide, push away, come between, disaffect, separate

disintegrate, disassemble, detach, segregate, disarticulate, dissociate, cleave, dissect, pare, remove, insulate, sever, disjoin, unglue, dismantle, excise, break, bisect, disassociate, rip, scissor, disconnect, part, unfix, fragment, unhinge, slice, split, sunder, disaffiliate, halve, uncouple, rend, incise, axe, cut, disengage, amputate

Usage examples:

• He was her knight and she his lady, so he must render her obedience, and she would use it to estrange him from the vanity of the world and make him a champion of the holy cause of the Church of Christ, the victorious conqueror of her foes. - "The Complete Historical Romances of Georg Ebers", Georg Ebers.
• Shake we off these violent hold- fasts which elsewhere engage us, and estrange us from ourselves. - "Montaigne and Shakspere", John M. Robertson.
• He must have had plenty of time and opportunity to discover Miss Lumley's intellectual limitations during the two years of his courtship; and it is not likely that, even if they were as well marked as Mrs. Shandy's own, they would have done much of themselves to estrange the couple. - "Sterne", H.D. Traill.