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Definition of estrange:

  1. To alienate the affections or confidence of; to turn from attachment to enmity or indifference.
  2. To divert from its original use or purpose, or from its former possessor; to alienate.
  3. To withdraw; to withhold; hence, reflexively, to keep at a distance; to cease to be familiar and friendly with.

Synonyms:

alien, alienate, sour, disgruntle, disaffect, set at odds, love.

Usage examples: