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Definition of exhaustion : 1. An ancient geometrical method in which an exhaustive process was employed. It was nearly equivalent to the modern method of limits.
2. The act of draining out or draining off; the act of emptying completely of the contents.
3. The state of being exhausted or emptied; the state of being deprived of strength or spirits.

Synonyms:

enfeeblement, tired

drainage, secretion, emission, expulsion, eruption, evacuation, seepage, exudation, excretion, rejection, disgorgement, ejaculation, ejection

dispossession, erosion, debit, penalty, privation, expropriation, deprivation, divestiture, setback, decrease, dissipation, forfeiture, ruin, depletion, loss, shrinkage, decrement, attrition, dissolution

drowsiness, apathy, faintness, over-weariness, listlessness, lassitude, cheerlessness, footsoreness, sleepiness, boredom, blues, ennui, tiredness, droopiness, weakness, feebleness, tedium, weariness, debilitation, depression, fatigue, flaccidity

lethargy, enervation, sluggishness

Usage examples:

• They generally go right to sleep from exhaustion. - "Ethel Morton at Chautauqua", Mabell S. C. Smith.
• When he tried to go on he was overcome with exhaustion. - "The Instant of Now", Irving E. Cox, Jr..
• " And I have had nothing for these two days," replied Nicholas, leaning back to the wall in evident exhaustion. - "Newton Forster", Frederick Marryat.