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Definition of extirpate : To pluck up by the stem or root; to root out; to eradicate, literally or figuratively; to destroy wholly; as, to extirpate weeds; to extirpate a tumor; to extirpate a sect; to extirpate error or heresy.

Synonyms:

reverse, blot out, obliterate, nullify, root out, abrogate, supplant, overthrow, subvert, wipe out, make an end of, clear, kill, repeal, stamp out, revoke, liquidate, prohibit, put an end to, help, uproot, snuff out, kill off, extinguish, end, do away with, deracinate, carry off, rub out, set aside, abate, erase, suppress, study at exterminate, terminate, make, annul

devastate, pulverize, lay waste, dismantle, abolish, level, exterminate, disintegrate, demolish, decimate, tear down, rip to shreds, mow down, wreck, atomize, desolate, eradicate, destroy, raze, vaporize, smash, bulldoze, annihilate, flatten

blacklist, deport, cordon, exile, boycott, banish, eliminate, sequester, expatriate, exclude, extradite, segregate, confine, evict, cloister, detach, reject, excommunicate, oust, closet, isolate, alienate, expel, ostracize, screen, separate, seclude, blackball, insulate, remove, disbar, eject

Usage examples:

• The Bashaw is the famous Moorish commander who captured and beheaded Abd- El- Geleel, and who has sworn to extirpate not only the family of this Sheikh, but all the tribes subjected to his son. - "Travels in the Great Desert of Sahara, in the Years of 1845 and 1846", James Richardson.
• It meant to extirpate root and branch, from the Constitution the right of the South to count five slaves as three freemen, or five serfs as five freemen in the apportionment of representatives among the states. - "The Negro and the elective franchise. A Series Of Papers And A Sermon (The American Negro Academy. Occasional Papers, No. 11.)", Archibald H. Grimké, Charles C. Cook, John Hope, John L. Love, Kelly Miller, and Rev. Frank J. Grimké.
• The conduct of Mr. Hastings, in assisting to extirpate, for a sum of money to be paid to the Company, the innocent nation of the Rohillas, had drawn upon him the censure of the Court of Directors, and the unanimous censure of the Court of Proprietors. - "The Works of the Right Honourable Edmund Burke, Vol. VIII. (of 12)", Edmund Burke.