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Definition of fateful : 1. Having the power of serving or accomplishing fate.
2. Significant of fate; ominous.

Synonyms:

deadly, inglorious, cataclysmal, ignominious, fated, help, mordant, lethal, sinister, grave, inevitable, dire, black, decisive, hellfire, apocalyptic, unfortunate, certain, ruinous, dark, cataclysmic, momentous, bleak, smuggled, shameful, crucial, portentous, disgraceful, catastrophic, grim, decide, apocalyptical, black-market, ominous, fire-and-brimstone, prophetic, calamitous, direful, disastrous, warn, fatal, foreboding, critical, blackened, smutty, pitch-black, opprobrious, luck, pitch-dark, unlucky, dim, contraband, destructive, baneful, bootleg, prophetical

Usage examples:

• Moreover, I could not take back the fateful words that I had spoken on the stone of sacrifice. - "Montezuma's Daughter", H. Rider Haggard.
• But even as they were discussing the matter, irresolute, distressed, there was a ring at the bell; and in a moment who should enter the parlor, holding in her hand those fateful telegrams, but Miss Forrest herself? - "'Laramie;' or, The Queen of Bedlam.", Charles King.
• At dawn, when the first rays of the sun lit up the Biggersbergen in all their grotesque beauty, I realised for the first time where I was, and found that I was considerably more than 12 miles from Elandslaagte, the fateful scene of yesterday. - "My Reminiscences of the Anglo-Boer War", Ben Viljoen.