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Definition of fatigue : 1. The cause of weariness; labor; toil; as, the fatigues of war.
2. The weakening of a metal when subjected to repeated vibrations or strains.
3. To weary with labor or any bodily or mental exertion; to harass with toil; to exhaust the strength or endurance of; to tire.
4. Weariness from bodily labor or mental exertion; lassitude or exhaustion of strength.

Synonyms:

have on, play out, become flat, fag, jade, fag out, die, tire out, fall apart, fatigue duty, frighten away, labor, assume, scare away, dash, grind, harass, dig, put on, cloy, moil, break, daunt, bear, endure, hold out, bust, scare, scare off, wear upon, pall, wear thin, get into, drudge, toil, labour, don, wear off, outwear, run down, travail, tired, frighten off

dull, sedate, bore, annoy, tire, weary, tranquilize

flag, enervation, wear, frazzle, tucker, wear down, lethargy, sluggishness, wear out

droopiness, flaccidity, cheerlessness, tedium, debilitation, exhaustion, battle fatigue, heaviness, burnout, weariness, anoxia, ennui, blues, boredom, tiredness, nervous exhaustion, drowsiness, weakness, feebleness, lassitude, dullness, listlessness, faintness, apathy, depression, combat fatigue, over-weariness, prostration, languor, footsoreness, sleepiness

exhaust, empty, sap, tap, drain, enervate, dissipate, debilitate

Usage examples:

• His eye would be able to group the whole in an instant, without effort, and without fatigue. - "A Practical Enquiry into the Philosophy of Education", James Gall.
• Her feet gave out sooner than her brain, though; and she got so tired before long, that she dropped into a seat, with a long- drawn, anxious sigh; and, worn out with fatigue and watching, she, at last, fell asleep. - "The Midnight Queen", May Agnes Fleming.
• She was trembling from head to foot with cold and fatigue and nervous excitement. - "The Christmas Story from David Harum", Edward Noyes Westcott.