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Definition of grief : 1. Cause of sorrow or pain; that which afficts or distresses; trial; grievance.
2. Pain of mind on account of something in the past; mental suffering arising from any cause, as misfortune, loss of friends, misconduct of one's self or others, etc.; sorrow; sadness.
3. Physical pain, or a cause of it; malady.

Synonyms:

heartbreak, botheration, sorrowfulness, anxiety, wo, be harmed, vexation, bother, have trouble, wretchedness, brokenheartedness, suffer, be unsuccessful, smart, despondency, exasperation, gloom, fail, happy, aggravation, mourning, disappointment, bereavement, mortification, happiness, depression, despair, frustration, dole, ruefulness, pip, disquiet, worry, unhappiness, exhilaration, aggro, desolation, harassment, sadness

destitution, bane, blight, adversity, burden, hard luck, contretemps, ordeal, catastrophe, curse, mishap, disaster, misadventure, hard times, peril, calamity, trouble, misfortune, tribulation, poorness, dolor, trial, hardship, tragedy, casualty, rainy day, difficulty, bad luck, woe, poverty

gripe, spasm, hurt, burn, inflammation, stitch, painfulness, suffering, wound, stab, malaise, earache, smarting, cramp, bite, crick, sting, migraine, pain, pang, rack, torment, back-ache, injury, headache, distress, sore, agony, ache, affliction, irritation, anguish, wrench, throe, torture, misery, discomfort, infliction, bruise, throb, chafing

contrition, sorriness, penitence, repentance, qualm, regret, sorrow, rue, remorse, shame, contriteness, heartache, lamentation

mournfulness, melancholy, plaintiveness, ululation, woefulness, dolefulness

Usage examples:

• All the wide world saw never greater grief!" - "The Legends Of King Arthur And His Knights", James Knowles.
• Poor Antoinette, mad with grief, left the stage, and went with her little boy to live in the Pollet, near her parents. - "The Martian", George Du Maurier.
• Yes, grief; you would not ask the question if you knew what it was. - "Maria The Wrongs of Woman", Mary Wollstonecraft.