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Definition of heartache : Sorrow; anguish of mind; mental pang.

Synonyms:

heartbreak, anguish, despair, happy, brokenheartedness

contrition, sorriness, penitence, repentance, qualm, regret, sorrow, rue, remorse, shame, contriteness, grief, lamentation

Usage examples:

• If everyone had a heartache like hers, or even the memory of such a heartache, it would make too monstrous a world, too deplorable a human race.
• Had he spoken frankly he would have saved Elsa many a bitter heartache, many a weary day. - "Parrot & Co.", Harold MacGrath.
• Greek, for once, failed to ease his heartache, and the Iliad seemed singularly over- strained and deadly dull. - "God's Good Man", Marie Corelli.