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Definition of insane : 1. Causing insanity or madness.
2. Characterized by insanity or the utmost folly; chimerical; unpractical; as, an insane plan, attempt, etc.
3. Exhibiting unsoundness or disorded of mind; not sane; mad; deranged in mind; delirious; distracted. See Insanity, 2.
4. Used by, or appropriated to, insane persons; as, an insane hospital.

Synonyms:

haywire, distracted, madcap, jerky, distraught, cockeyed, knowledge, zany, amuck, wrong, unrestrained, cracked, whacky, raving, demoniacal, daft, amok, softheaded, non compos mentis, bats, hebephrenic, kookie, half-crazed, demoniac, moonstruck, screwy, tomfool, brainsick, preposterous, sappy, off, screw-loose, loony, loopy, crackers, psychopathologic, buggy, round the bend, nuts, mentally ill, around the bend, nonsensical, unearthly, dippy, maniac, certifiable, dotty, certified, silly, gaga, stupid, unhinged, idiotic, daffy, moronic, wacky, crazed, crackbrained, raving mad, foolish, touched, ability, unstable, excited, psychopathic, loco, possessed, maniclike, sick, harebrained, schizophrenic, unsound, dopey, paranoid, imbecilic, huffy, psychopathological, fruity, of unsound mind, noncompos mentis, bonkers, absurd, fey, disturbed, barmy, balmy, sore, manic-depressive

shapeless, disorganized, cluttered, lax, inexact, irregular, inchoate, confused, disarrayed, tumultuous, inconsistent, out of control, embroiled, deformed, perturbed, unruly, deranged, undisciplined, wild, messy, formless, loose, chaotic, tempestuous, disconnected, discomposed, disordered, rambunctious, incoherent, blurry, indefinite, muddled, obscure, lawless, jumbled, frantic, fuzzy, frenzied, amorphous, disorderly, anarchical, disheveled, indistinct, uneven, anarchistic, disintegrated

delirious, babbling, feverish, neurotic, maniacal, mad, blithering, lunatic, nutty, berserk, batty, demented, psychotic, crazy, schizoid, irrational, psycho, unbalanced, brain-sick, crack-brained, hysterical, kooky

rabid, raging, addleheaded, bananas, obsessed, addlepated, pixilated, gone, cuckoo, sane, deluded, unsettled, violent, rational

Usage examples:

• " Why," I began, very much surprised, " does anybody doubt that she is insane?" - "Paul Patoff", F. Marion Crawford.
• When he is wrought up he is insane. - "The Desired Woman", Will N. Harben.
• As has been said so often before in this book, the worse and insane side of Oscar Wilde must always obscure and conquer the better and beautiful side of him. - "Oscar Wilde", Leonard Cresswell Ingleby.