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Definition of irritability:

  1. A condition of morbid excitability of an organ or part of the body; undue susceptibility to the influence of stimuli. See Irritation, n., 3.
  2. A natural susceptibility, characteristic of all living organisms, tissues, and cells, to the influence of certain stimuli, response being manifested in a variety of ways, -- as that quality in plants by which they exhibit motion under suitable stimulation; esp., the property which living muscle processes, of responding either to a direct stimulus of its substance, or to the stimulating influence of its nerve fibers, the response being indicated by a change of form, or contraction; contractility.
  3. The state or quality of being irritable; quick excitability; petulance; fretfulness; as, irritability of temper.

Synonyms:

toughness, fussiness, crossness, annoyance, anger, excitability, biliousness, yellow bile, irritation, ire, snappishness, pettishness, fretfulness, temper, humor, mood, impatience, pique, peevishness, surliness, petulance, humour, crabbiness, choler.

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