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Definition of irritation : 1. A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action.
2. The act of exciting, or the condition of being excited to action, by stimulation; -- as, the condition of an organ of sense, when its nerve is affected by some external body; esp., the act of exciting muscle fibers to contraction, by artificial stimulation; as, the irritation of a motor nerve by electricity; also, the condition of a muscle and nerve, under such stimulation.
3. The act of irritating, or exciting, or the state of being irritated; excitement; stimulation, usually of an undue and uncomfortable kind; especially, excitement of anger or passion; provocation; annoyance; anger.

Synonyms:

mood, pain in the neck, rage, anger, toughness, fervour, impatience, menace, rawness, annoying, aggravator, bothering, peeve, drag, plague, nuisance, excitement, pest, biliousness, fervor, choler, joke, concern, feelings, pain in the ass, irritability, fretfulness, tenderness, pip, outrage, besetment, surliness, fury, temper, asperity, stress, aggro, humour, upset, calamity, neuralgia, animosity, peevishness, snappishness, incitement, help, eina, botheration, irritant, pestering, incitation, humor, worry, pettishness, excitation, chafe, passion, innervation

discontentment (part of speech: noun)

displeasure, despondence, sourness, joylessness, inquietude, anxiety, ennui, angst, disgruntlement, disquiet, unhappiness, gloominess, frustration, boredom, wretchedness, non-satisfaction, uneasiness, cheerlessness

pain (part of speech: noun)

grief, spasm, headache, burn, hurt, stitch, painfulness, suffering, wound, stab, malaise, earache, smarting, cramp, bite, crick, sting, migraine, pain, pang, rack, torment, back-ache, infliction, gripe, distress, sore, agony, ache, affliction, injury, anguish, wrench, throe, torture, misery, discomfort, inflammation, bruise, throb, chafing

aggravation (part of speech: noun)

disturbance, bedevilment, ire, harassment, bother, arousal, petulance, exasperation, provocation, scorn, trouble, virulence, discomposure, exacerbation, enragement, annoyance, perturbation

painfulness (part of speech: noun)

aggravation, severity, distressfulness, uncomfortableness, woefulness, acuteness, annoyingness, odiousness, oppressiveness, unpleasantness, irksomeness, grievousness, offensiveness, arduousness, cruelty, hurtfulness

sensitivity (part of speech: noun)

susceptibility, sensitivity, susceptibleness

resentment (part of speech: noun)

hard feelings, acerbity, ill humor, soreness, resentment, rancor, bitterness, pique, spite, bile, antagonism, huffiness, umbrage, envy, vexation, infuriation, sullenness, wrath, discontent, dissatisfaction, indignation, offense

Usage examples: