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Definition of loco:

  1. A direction in written or printed music to return to the proper pitch after having played an octave higher.
  2. A locomotive.
  3. A plant ( Astragalus Hornii) growing in the Southwestern United States, which is said to poison horses and cattle, first making them insane. The name is also given vaguely to several other species of the same genus. Called also loco weed.
  4. Any one of various leguminous plants or weeds besides Astragalus, whose herbage is poisonous to cattle, as Spiesia Lambertii, syn. Oxytropis Lambertii.
  5. To poison with loco; to affect with the loco disease; hence ( Colloq.), to render insane or mad.

Synonyms:

wrong, meshuga, unsound, mad, silly, bedlam, crackbrained, bananas, touched, soft, nutty, laughable, batty, gaga, fruity, cranky, non compos mentis, kookie, bughouse, bats, crazy, scatty, deranged, childish, not in your right mind/not right in the head, maniacal, balmy, whacky, psycho, cuckoo, chapped, daft, goofy, around the bend, maniac, barmy, amiss, cockamamie, ludicrous, nuts, crazy as a loon, mental, bonkers, mentally ill, not all there, distraught, brainsick, sick in the head, screwy, demented, disordered, certifiable, roughened, yeasty, round the bend, dotty, crazed, cracked, daffy, haywire, mild, insane, sane, awry, buggy, loopy, psychotic, wacky, kooky, alligatored, sappy, wud, unbalanced, crackers, stark raving mad, crackpot, moonstruck, nutty as a fruitcake, zestful, lunatic, mad as a hatter, zany, off, nutlike, zesty, loony tunes, wacko, unhinged, of unsound mind, ridiculous, over-the-top, wild, cockamamy, loony.

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