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Definition of lonesome : 1. Conscious of, and somewhat depressed by, solitude; as, to feel lonesome.
2. Secluded from society; not frequented by human beings; solitary.

Synonyms:

dejected, morose, sole, secluded, cloudy, alienated, dreich, dismal, isolated, dark, alone, dire, outermost, apart, miserable, include, companionless, bleak, funereal, homesick, saturnine, desolate, depressive, back, sepulchral, estranged, drear, murky, solitary, darkening, somber, wretched, solemn, unfrequented, distant, away, study at alone, cheerless, adrift, black, lonely, removed, plutonian, lorn, obscure, lugubrious, forlorn, gray, tenebrific, inaccessible, out-of-the-way, deserted, Cimmerian, far, disconsolate, comfortless, morbid, full, elegiac, Godforsaken, insular, tenebrous, lone, near, friendless, solo, unaccompanied, sullen, outlying, depressing, only, remote, chill, glum, dreary, happy, cold, single, sunless, abandoned

Usage examples:

• It wouldn't be so lonesome. - "Thankful Rest", Annie S. Swan.
• " And if it wasn't for being busy I'd be dreadfully lonesome without you, too," admitted Bobby. - "Bobby of the Labrador", Dillon Wallace.
• This morning I was lonesome and wished something pleasant would happen. - "Marjorie Dean College Freshman", Pauline Lester.