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Definition of malaise : An indefinite feeling of uneasiness, or of being sick or ill at ease.

Synonyms:

inquietude, disquietude, depression, self-consciousness, uneasiness, uncomfortableness, edginess, unease, restlessness, disquiet, despair

illness, infirmity, affection, malady, feverishness, syndrome, debility, condition, apoplexy, disability, indisposition, decrepitude, disorder, fever, sickness, queasiness, disease, collapse, virus, unhealthiness, curse, ague, symptom, ailment, breakdown, attack, sickliness, handicap, pestilence, complication, complaint, infection, bug, nausea

grief, spasm, headache, burn, hurt, stitch, painfulness, suffering, wound, stab, irritation, earache, smarting, cramp, bite, crick, sting, migraine, pain, pang, rack, torment, back-ache, infliction, gripe, distress, sore, agony, ache, affliction, injury, anguish, wrench, throe, torture, misery, discomfort, inflammation, bruise, throb, chafing

Usage examples:

• The Modified Small- pox- that is to say, small- pox that has been robbed of its virulence by the patient having been either already vaccinated, or by his having had a previous attack of small- pox- is ushered in with severe symptoms, with symptoms almost as severe as though the patient had not been already somewhat protected either by vaccination or by the previous attack of small- pox- that is to say, he has a shivering fit, great depression of spirits and debility, malaise, sickness, headache, and occasionally delirium. - "Advice to a Mother on the Management of her Children", Pye Henry Chavasse.
• There have always been, and always will be, people who experience a sort of malaise, an ill- defined discomfort, as though they sat in an east wind, while they read La Rochefoucauld. - "Three French Moralists and The Gallantry of France", Edmund Gosse.
• Whatever else he did, he must get rid of that malaise! - "The Patrician", John Galsworthy.