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Definition of malignant : 1. A man of extrems enmity or evil intentions.
2. Characterized or caused by evil intentions; pernicious.
3. Disposed to do harm, inflict suffering, or cause distress; actuated by extreme malevolence or enmity; virulently inimical; bent on evil; malicious.
4. One of the adherents of Charles L. or Charles LL.; - so called by the opposite party.
5. Tending to produce death; threatening a fatal issue; virulent; as, malignant diphtheria.

Synonyms:

despiteful, bitchy, help, pernicious, attitude, black, malign, cancerous

dangerous, corrupt, harmful, deleterious

infected, deadly, poisonous, pestilent, diseased, contaminated, toxic, pathological, unhealthy, unhygienic, unsanitary, unwholesome, gangrenous, noxious, insalubrious, contagious, septic

black-hearted, ill-natured, hurtful, malicious, hateful, sullen, evil, mean, malevolent, rancorous, venomous, corrosive, virulent, spiteful, antagonistic, perfidious, catty, wicked, sinister, churlish, bitter, baleful, treacherous, vicious, nasty, vindictive, foul, baneful, hostile

internecine, fatal, lethal, mortal, pestilential, destructive

Usage examples:

• In any case, could malignant fortune have posted, at this place and hour, a more dangerous watcher? - "The Room in the Dragon Volant", J. Sheridan LeFanu.
• Then all the sky grew dark, and from the land Malignant terrors drove me shrieking forth; And as I fled, my youth abandoned me; My hair turned gray, my shoulders stooped, my blood Grew colder, and my perfect form was changed. - "Stories in Verse", Henry Abbey.
• There was comfort in the thought that they were not active and malignant in their enmity. - "The Lost Trail", Edward S. Ellis.