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Definition of nettlesome : causing irritation or annoyance; " tapping an annoying rhythm on his glass with his fork"; " aircraft noise is particularly bothersome near the airport"; " found it galling to have to ask permission"; " an irritating delay"; " nettlesome paperwork"; " a pesky mosquito"; " swarms of pestering gnats"; " a plaguey newfangled safety catch"; " a teasing and persistent thought annoyed him"; " a vexatious child"; " it is vexing to have to admit you are wrong"

Synonyms:

pesty, raspy, testy, plaguy, pain, disagreeable, irritative, tender, exasperating, tippy, abrasive, irritating, mocking, quizzical, disturbing, thorny, techy, frustrating, excitable, ill-natured, prickly, spiny, irritable, pettish, irksome, riling, maddening, petulant, peevish, rankling, refractory, uneven, annoying, provoking, scratchy, teasing, peckish, recalcitrant, vexatious, carking, pesky, rebarbative, pestiferous, infuriating, vexing, pestilent, chafing, peeving, perversive, spotty, corruptive, cranky, crank, bothersome, aggravating, tetchy, fractious, pestering, nettling, dirty, rasping, pestilential, grating, painful, plaguey, galling, troublesome, easy, gravelly, rough