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Definition of perturbation : 1. A disturbance in the regular elliptic or other motion of a heavenly body, produced by some force additional to that which causes its regular motion; as, the perturbations of the planets are caused by their attraction on each other.
2. The act of perturbing, or the state of being perturbed; esp., agitation of mind.

Synonyms:

hoo-ha, unease, concern, hurly burly, upset, apprehensiveness, stew, disquietude, kerfuffle, mental disorder, fluster, hoo-hah, affray, anxiety, overturn, fear, solicitude, care, break, nervosity, dislocation, sweat, apprehension, psychological disorder, uneasiness, overthrow, gap, disruption, concernment, ruffle, turnover, interruption, anxiousness, interference, nervousness, worry, flutter, noise, swage, lather, folie, dither, fray, agita, to-do, mental disturbance, calm

exacerbation, provocation, irritation, harassment, aggravation, petulance, inflammation, exasperation, discomposure, bother, trouble, scorn, pique, virulence, arousal, disturbance, indignation, enragement, resentment, vexation, torment, bedevilment, annoyance, ire

formlessness, anarchism, inchoateness, disconnectedness, dishevel, muddlement, lawlessness, inexactness, obscurity, amorphousness, unevenness, chaos, disarray, messiness, confusion, shapelessness, deformity, incoherence, looseness, anarchy, inconsistency, clutter, irregularity, disintegration, tumult, entropy, frenzy, disorderliness, mess, disorganization, insanity, derangement, indefiniteness, laxity, indistinctness, fuzziness

disarrangement, agitation, jerkiness, disorder, disquiet, palpitation, commotion, convulsion, turmoil

Usage examples:

• She rose in perturbation.
• My mind, during the few past days, seemed, as it were, disengaged from my body; but, now the struggle was over, I felt very forcibly the effect which perturbation of spirits produces on a woman in my situation. - "Maria The Wrongs of Woman", Mary Wollstonecraft.
• She dared not say so in their visitor's presence, but she wondered mightily at Phoebe's apparent perturbation. - "The Panchronicon", Harold Steele Mackaye.