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Definition of pestilence:

  1. Fig.: That which is pestilent, noxious, or pernicious to the moral character of great numbers.
  2. Specifically, the disease known as the plague; hence, any contagious or infectious epidemic disease that is virulent and devastating.

Synonyms:

canker, contagion, gadfly, pestis, infestation, pest, epidemic, endemic, pesterer, plague, blighter, canker sore, cuss.

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