barmy, bats, nuts, crackers, buggy, dotty, around the bend, haywire, kookie, wacky, unsmooth, kooky, bonkers, round the bend, loco, daft, cracked, batty, loony, nutty, whacky, chapped, rough, loopy, alligatored, fruity, balmy
deranged (part of speech: verb)
disorganized, whisked, confounded, mixed up muddled, confused, ruffled, jumbled, messed, scattered, mislaid, tumbled, convulsed, rumpled, upset, whipped, discomposed, tousled, capsized, rummaged, botched, displaced, disturbed, troubled, tampered, rippled, hashed, misplaced, mussed, perturbed, cluttered, agitated, swirled, disarranged, fermented, deranged, blurred, roiled, disheveled, scrambled, tossed, dislocated, meddled, disordered, churned
roughened (part of speech: verb)
- He noted too, as the needle went in and out of the fabric, that her hands, though roughened by coarse work, were finely made, with long fingers and delicate wrists. - "The Rough Road", William John Locke.
- Often at night as he saw her lying asleep, her long lashes upon her roughened sun- burned skin, his heart went out to her in a great gush of tenderness. - "Rose of Dutcher's Coolly", Hamlin Garland.
- He wrapped a handkerchief about this wound, and took the pistol out, deriving a great deal of comfort from the way it balanced, its roughened grip nestling snugly in his palm. - "The Bronze Bell", Louis Joseph Vance.