SPIGELIUS'S LINE
\spˈa͡ɪd͡ʒlɪəsɪz lˈa͡ɪn], \spˈaɪdʒlɪəsɪz lˈaɪn], \s_p_ˈaɪ_dʒ_l_ɪ__ə_s_ɪ_z l_ˈaɪ_n]\
Definitions of SPIGELIUS'S LINE
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.