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Definition of tragedy : 1. A dramatic poem, composed in elevated style, representing a signal action performed by some person or persons, and having a fatal issue; that species of drama which represents the sad or terrible phases of character and life.
2. A fatal and mournful event; any event in which human lives are lost by human violence, more especially by unauthorized violence.

Synonyms:

lot, fortune, struggle, humiliation, wreck, success, help, novel, happiness, failure, play, cataclysm, doom, prosperity, satire

characterization, mystery, mime, panorama, improvisational drama, skit, excitement, pantomime, pageant, rendering, suspense, drama, variety, show, art, production, choreography, vaudeville, scene, comedy, burlesque, ballet, spectacle, teleplay, presentation, theater, improvisation, Broadway, melodrama

distress, affliction, hard luck, catastrophe, contretemps, torment, ordeal, misery, trial, adversity, woe, bad luck, casualty, rainy day, blight, tribulation, burden, hard times, poorness, agony, hardship, bane, mishap, curse, trouble, disaster, dolor, destitution, poverty, difficulty, misfortune, calamity, infliction, peril, misadventure, grief

Usage examples:

• It's a great human tragedy. - "Hoofbeats on the Turnpike", Mildred A. Wirt.
• Any of you who have had much to do with one stricken with a sore disease, who knows he never can be well again, know that it is not the sickness, the physical weakness and pain that make the problem and the tragedy. - "Frank H. Nelson of Cincinnati", Warren C. Herrick.
• Clithering had been with me, off and on, most of the day, so I had got rather tired of tragedy. - "The Red Hand of Ulster", George A. Birmingham.