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Definition of up:

  1. Aloft; on high; in a direction contrary to that of gravity; toward or in a higher place or position; above; - the opposite of down.
  2. Aside, so as not to be in use; as, to lay up riches; put up your weapons.
  3. From a lower to a higher place on, upon, or along; at a higher situation upon; at the top of.
  4. From the coast towards the interior of, as a country; from the mouth towards the source of, as a stream; as, to journey up the country; to sail up the Hudson.
  5. In a higher place or position, literally or figuratively; in the state of having arisen; in an upright, or nearly upright, position; standing; mounted on a horse; in a condition of elevation, prominence, advance, proficiency, excitement, insurrection, or the like; -- used with verbs of rest, situation, condition, and the like; as, to be up on a hill; the lid of the box was up; prices are up.
  6. Inclining up; tending or going up; upward; as, an up look; an up grade; the up train.
  7. The state of being up or above; a state of elevation, prosperity, or the like; - rarely occurring except in the phrase ups and downs.
  8. To or in a position of equal advance or equality; not short of, back of, less advanced than, away from, or the like; -- usually followed by to or with; as, to be up to the chin in water; to come up with one's companions; to come up with the enemy; to live up to engagements.
  9. To or in a state of completion; completely; wholly; quite; as, in the phrases to eat up; to drink up; to burn up; to sum up; etc.; to shut up the eyes or the mouth; to sew up a rent.
  10. Upon.

Synonyms:

under, au courant, current, abroad, downriver, advancing, ascending, declining, ended, apart, toss and turn, from all sides, functioning, upwardly, by, case-sensitive, go through the roof, in the lead, direct, around, go up, concluded, downward, step up, Arctic, upwards, age bracket, bouncy, outside, growing, down, clickable, insomnia, forward, add to, Anglo-American, higher, versed, peer, outdated, heavenward, fourfold, past, upriver, oncoming, graduated, depleted, dormy, well-informed, accumulative, heightened, up-to-date, uphill, against, prepared, across, Baltic, jacked, abreast, downstream, sprouted, raised, escalated, antivirus, increased, anymore, bursty, elate, active, Anglo-Saxon, skyward, run out, conversant, age gap, finished, American, after, acquainted, escalate, prospective, conscious, compatibility, knowledgeable, onward, dormie, contemporary, asynchronous, sleepless, current, bad night, anglophone, along, upward, backward-compatible, multiply, happy, terminated, continental, completed, at, backward, risen, continuing, overjoyed, elevated, astir, bicoastal, before, exhausted, back, waking, increase, age, soar, compatible, aweigh, old, about, done, gathering, awake, exponential, exponential, wakeful, over with, away, following, invalid, double, beyond, mission accomplished, through, coast-to-coast, into, elated, leading, lapsed, upfield, aged, over, at an end, upstream, bound for something, complete, improving, ahead, raise, upbound, informed, rising, best-of-breed.

Usage examples:

  • What's she been up to?

    - "The Salamander", Owen Johnson.
  • We must give it up!

    - "The Quality of Mercy", W. D. Howells.
  • He got up now.

    - "The Wrong Twin", Harry Leon Wilson.