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Definition of weaken : 1. To become weak or weaker; to lose strength, spirit, or determination; to become less positive or resolute; as, the patient weakened; the witness weakened on cross- examination.
2. To make weak; to lessen the strength of; to deprive of strength; to debilitate; to enfeeble; to enervate; as, to weaken the body or the mind; to weaken the hands of a magistrate; to weaken the force of an objection or an argument.
3. To reduce in quality, strength, or spirit; as, to weaken tea; to weaken any solution or decoction.

Synonyms:

give, relegate, resign, erupt, enervate, conk out, mute, go, break in, better, unnerve, damp, get out, transgress, let out, go against, stifle, counteract, part, countervail, relent, moderate, intermit, flag, subvert, languish, ease off, degenerate, undo, reduce, buffer, cushion, check, deteriorate, quicken, dampen, bring out, bankrupt, violate, countercheck, break up, antagonize, minimize, snap off, impoverish, fall apart, wash, breach, give out, fizzle, discover, animate, debase, cave, recrudesce, thin, leave office, come apart, tremble, wash up, crack, sink, lessen, pervert, crack up, bump, overthrow, wilt, go bad, break away, emasculate, collapse, offend, break off, cut, decline, halt, cave in, wear out, burst, relax, relapse, separate, decrease, bring down, unwrap, limp, develop, yield, overturn, tone down, deprave, waste, stop, demoralise, step-down, ruin, mince, totter, revive, wear, crumble, infract, abate, bust, disclose, reveal, increase, castrate, faint, smash, countermine, break-dance, demoralize, moisten, let on, break out, strong, interrupt, fracture, devitalize, split, corrupt, give away, wane, break, break down, demote, pause, get around, sabotage, lose, give way, muffle, fail, misdirect, discontinue, water, de-escalate, slacken, profane, attenuate, exhaust, quit, fall in, antagonise, debauch, divulge, die, counterbalance, fade, dilute, founder, strengthen, kick downstairs, split up, droop, expose

enfeeble, incapacitate, deaden, stupefy, disarm, hinder, benumb, lame, cripple, vitiate, abrogate, handicap, botch, cramp, tamper, sap, hamper, undermine, impair, paralyze, hamstring, prostrate, hobble, anesthetize, dull, disable, scotch, screw up, neutralize, invalidate, stun

debilitate, soften

Usage examples:

• The raid of 1918 did not weaken the lumber workers' Union in Centralia. - "The Centralia Conspiracy", Ralph Chaplin.
• " I hate to see a man weaken. - "Jeanne of the Marshes", E. Phillips Oppenheim.
• Germany thus needed to concentrate all of her available submarines at these points; she had an inadequate number for her purpose; to send any considerable force three thousand miles across the Atlantic would simply weaken her efforts in the real scene of warfare and would make her submarine campaign a failure. - "The Victory At Sea", William Sowden Sims Burton J. Hendrick.