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characterized by toilsome effort to the point of exhaustion; especially physical effort; "worked their arduous way up the mining valley"; "a grueling campaign"; "hard labor"; "heavy work"; "heavy going"; "spent many laborious hours on the project"; "set a punishing pace"
By Princeton University
Word of the day
Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.