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Definition of trouble:

1. A fault or interruption in a stratum.
2. That which gives disturbance, annoyance, or vexation; that which afflicts.
3. The state of being troubled; disturbance; agitation; uneasiness; vexation; calamity.
4. To disturb; to perplex; to afflict; to distress; to grieve; to fret; to annoy; to vex.
5. To give occasion for labor to; - used in polite phraseology; as, I will not trouble you to deliver the letter.
6. To put into confused motion; to disturb; to agitate.
7. Troubled; dark; gloomy.

Synonyms:

rag, apprehension, anguish, discomfort, spot, anesthetise, tump over, pickle, handful, inconvenience oneself, interrupt, bowl over, hurt, striving, intrusion, disarray, exigency, difficultness, hot water, struggle, foreboding, box, effort, gossip, plight, easy, pain in the neck, shake up, intruder, dread, care, corner, release, quagmire, anxiety, overturn, spat, dither, brat, commove, flurry, hole, headache, difficulty, cark, troublemaker, scrape, bind, fretfulness, feud, swage, issue, hold out, gravel, distract, fuss, endeavor, solicitude, riot, elbow grease, while, problem, work, touch, concern, predicament, afflict, botheration, stretch out, get at, douse, dispute, bore, dilemma, hot spot, get to, soup, put under, nettle, disease, meddler, smart aleck, discomfit, raise up, stir up, perturb, exertion, crisis, turn over, task, strife, ailment, throw out of kilter, bother, pettifoggery, exigence, exsert, fretting, bring out, help, nuisance, inconvenience, squabble, fight, turmoil, pain in the ass, bickering, pother, hassle, disconcert, flap, scuffle, pest, jam, rough-and-tumble, aid, puzzle, disoblige, knock over, smother, bicker, incommodiousness, tip over, delay, rile, fear, tussle, disquiet, disorder, strain, unhinge, injury, hindrance, worry, malady, anaesthetise, retire, tizzy, ail, devil, fix, nark, hustle, untune, anesthetize, hang-up, incommodity, discommode, perplexity, anaesthetize, trouble oneself, case, bustle, extend, dogfight, misgiving, stretch forth, argument, put out, Dutch, deflect, job, quarrel, comfort, publish, tiff, ado, pain, incommode, deep water.

• aggravate (part of speech: verb)
  • envenom, 
  • harass, 
  • fret, 
  • infuriate, 
  • disturb, 
  • bait, 
  • hassle, 
  • bother, 
  • bedevil, 
  • pester, 
  • envenom, 
  • enrage, 
  • arouse, 
  • irk, 
  • rankle, 
  • tease, 
  • exacerbate, 
  • inflame, 
  • aggravate, 
  • exasperate, 
  • annoy, 
  • nag, 
  • irritate, 
  • needle, 
  • peeve, 
  • grate, 
  • perturb, 
  • chafe, 
  • upset, 
  • torment, 
  • badger, 
  • discompose, 
  • harry, 
  • vex, 
  • antagonize
• aggravation (part of speech: noun)
  • exacerbation, 
  • pique, 
  • irritation, 
  • harassment, 
  • aggravation, 
  • perturbation, 
  • inflammation, 
  • exasperation, 
  • discomposure, 
  • bother, 
  • torment, 
  • resentment, 
  • petulance, 
  • virulence, 
  • arousal, 
  • disturbance, 
  • indignation, 
  • enragement, 
  • provocation, 
  • vexation, 
  • scorn, 
  • bedevilment, 
  • annoyance, 
  • ire
• adversity (part of speech: noun)
  • distress, 
  • affliction, 
  • hard luck, 
  • catastrophe, 
  • contretemps, 
  • torment, 
  • ordeal, 
  • misery, 
  • tragedy, 
  • adversity, 
  • woe, 
  • bad luck, 
  • casualty, 
  • rainy day, 
  • blight, 
  • trial, 
  • burden, 
  • hard times, 
  • poorness, 
  • agony, 
  • hardship, 
  • bane, 
  • mishap, 
  • curse, 
  • tribulation, 
  • disaster, 
  • dolor, 
  • destitution, 
  • poverty, 
  • difficulty, 
  • misfortune, 
  • calamity, 
  • infliction, 
  • peril, 
  • misadventure, 
  • grief
• agitate (part of speech: verb)
  • jolt, 
  • disquiet, 
  • quiver, 
  • quaver, 
  • fluster, 
  • churn, 
  • shiver, 
  • quake, 
  • shudder, 
  • stir, 
  • twitch, 
  • upset, 
  • jar, 
  • perturb, 
  • palpitate, 
  • agitate, 
  • shake
• difficulty (part of speech: noun)
  • stress, 
  • strain, 
  • struggle
• derange (part of speech: verb)
  • disorganize, 
  • convulse, 
  • discompose, 
  • disarrange, 
  • swirl, 
  • mix-up, 
  • rumple, 
  • derange, 
  • hash, 
  • displace, 
  • jumble, 
  • scramble, 
  • whisk, 
  • tamper, 
  • roughen, 
  • dislocate, 
  • mess, 
  • confuse, 
  • tousle, 
  • ripple, 
  • disturb, 
  • roil, 
  • churn, 
  • ruffle, 
  • misplace, 
  • meddle, 
  • dishevel, 
  • botch, 
  • capsize, 
  • mislay, 
  • confound, 
  • agitate, 
  • tumble, 
  • clutter, 
  • upset, 
  • scatter, 
  • rummage, 
  • perturb, 
  • ferment, 
  • muss, 
  • whip, 
  • disorder, 
  • toss, 
  • blur, 
  • muddle