ALBERT BITZIUS
\ˈalbət bˈɪtsɪəs], \ˈalbət bˈɪtsɪəs], \ˈa_l_b_ə_t b_ˈɪ_t_s_ɪ__ə_s]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.