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Definition of sis : 1. A colloquial abbreviation of Sister.
2. Six. See Sise.

Synonyms:

baby, babe, sister

Usage examples:

• I soaked that rough- neck, sis, and don't you forget it. - "The Desert of Wheat", Zane Grey.
• Sis, upon my word, that two weeks in the woods has made you real keen in argument; but you play abominably. - "The Chautauqua Girls At Home", Pansy, AKA Isabella M. Alden.
• I have made a good try of it, sis, but the big combinations are bound to have their way in the end. - "Joan of Arc of the North Woods", Holman Day.