COVARIATION
\kˌɒve͡əɹɪˈe͡ɪʃən], \kˌɒveəɹɪˈeɪʃən], \k_ˌɒ_v_eə_ɹ_ɪ__ˈeɪ_ʃ_ə_n]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.