DIFFUSE WELL DIFFERENTIATED LYMPHOCYTIC LYMPHOMA
\dɪfjˈuːz wˈɛl dˌɪfəɹˈɛnʃɪˌe͡ɪtɪd lˌɪmfəsˈɪtɪk lɪmfˈə͡ʊmə], \dɪfjˈuːz wˈɛl dˌɪfəɹˈɛnʃɪˌeɪtɪd lˌɪmfəsˈɪtɪk lɪmfˈəʊmə], \d_ɪ_f_j_ˈuː_z w_ˈɛ_l d_ˌɪ_f_ə_ɹ_ˈɛ_n_ʃ_ɪ__ˌeɪ_t_ɪ_d l_ˌɪ_m_f_ə_s_ˈɪ_t_ɪ_k l_ɪ_m_f_ˈəʊ_m_ə]\
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A low-grade malignant lymphoma that may, in some cases, be considered histologically identical to chronic lymphocytic leukemia (CLL; LEUKEMIA, LYMPHOCYTIC, CHRONIC). It is diffuse in pattern, representing the neoplastic proliferation of well-differentiated B-lymphocytes. In patients with immunoglobulin gammopathies, the lymphocytes may exhibit plasmacytoid characteristics.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.