PESSIMISTICAL
\pˌɛsɪmˈɪstɪkə͡l], \pˌɛsɪmˈɪstɪkəl], \p_ˌɛ_s_ɪ_m_ˈɪ_s_t_ɪ_k_əl]\
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By James Champlin Fernald
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.