RETRO-OPERATIVE

\ɹˌɛtɹə͡ʊˈɒpəɹətˌɪv], \ɹˌɛtɹə‍ʊˈɒpəɹətˌɪv], \ɹ_ˌɛ_t_ɹ_əʊ_ˈɒ_p_ə_ɹ_ə_t_ˌɪ_v]\
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1908 - Chambers's Twentieth Century Dictionary of the English Language
By Thomas Davidson

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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