AFLATOXIN M1, CIS(+ ) ISOMER
\ɐflˈatəksˌɪn ˈɛm wˈɒn], \ɐflˈatəksˌɪn ˈɛm wˈɒn], \ɐ_f_l_ˈa_t_ə_k_s_ˌɪ_n ˈɛ_m w_ˈɒ_n]\
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A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
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