FULMINANT HEPATIC FAILURE WITH CEREBRAL EDEMA
\fˈʊlmɪnənt hɛpˈatɪk fˈe͡ɪli͡ə wɪð səɹˈiːbɹə͡l ˈɛdɪmə], \fˈʊlmɪnənt hɛpˈatɪk fˈeɪliə wɪð səɹˈiːbɹəl ˈɛdɪmə], \f_ˈʊ_l_m_ɪ_n_ə_n_t h_ɛ_p_ˈa_t_ɪ_k f_ˈeɪ_l_iə w_ɪ_ð s_ə_ɹ_ˈiː_b_ɹ_əl ˈɛ_d_ɪ_m_ə]\
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A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); asterixis; NYSTAGMUS; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.