INSERTIONAL ACTIVATION
\ɪnsˈɜːʃənə͡l ˌaktɪvˈe͡ɪʃən], \ɪnsˈɜːʃənəl ˌaktɪvˈeɪʃən], \ɪ_n_s_ˈɜː_ʃ_ə_n_əl ˌa_k_t_ɪ_v_ˈeɪ_ʃ_ə_n]\
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Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA can be inserted into or adjacent to a cellular proto-oncogene. Insertion of the provirus can cause mutations by interrupting coding sequences or regulatory elements, or cause unregulated expression of the proto-oncogene resulting in tumor formation.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.