PRESENILE ALZHEIMER DEMENTIA
\pɹɪsˈɛna͡ɪl ˈaltsa͡ɪmə dɪmˈɛnʃə], \pɹɪsˈɛnaɪl ˈaltsaɪmə dɪmˈɛnʃə], \p_ɹ_ɪ_s_ˈɛ_n_aɪ_l ˈa_l_t_s_aɪ_m_ə d_ɪ_m_ˈɛ_n_ʃ_ə]\
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A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgement, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.