CREUX DE LAISSELLE

\krjˈuː də lˈe͡ɪsɛl], \krjˈuː də lˈe‍ɪsɛl], \k_r_j_ˈuː d_ə l_ˈeɪ_s_ɛ_l]\
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1846 - Medical lexicon: a dictionary of medical science
By Robley Dunglison

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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