OBSIGNATION
\ɒbsɪɡnˈe͡ɪʃən], \ɒbsɪɡnˈeɪʃən], \ɒ_b_s_ɪ_ɡ_n_ˈeɪ_ʃ_ə_n]\
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n. [Latin] The act of sealing ;— ratification by sealing ;— confirmation.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.