AY 22989
\ˈa͡ɪ twˈɛntitˈuː θˈa͡ʊzənd nˈa͡ɪnhˈʌndɹədən ˈe͡ɪtinˈa͡ɪn], \ˈaɪ twˈɛntitˈuː θˈaʊzənd nˈaɪnhˈʌndɹədən ˈeɪtinˈaɪn], \ˈaɪ t_w_ˈɛ_n_t_i_t_ˈuː θ_ˈaʊ_z_ə_n_d_ n_ˈaɪ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n ˈeɪ_t_i_n_ˈaɪ_n]\
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A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.