CRYSTALLINIC ACID
\kɹˌɪstɐlˈɪnɪk ˈasɪd], \kɹˌɪstɐlˈɪnɪk ˈasɪd], \k_ɹ_ˌɪ_s_t_ɐ_l_ˈɪ_n_ɪ_k ˈa_s_ɪ_d]\
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An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.