GABAERGIC MODULATORS
\d͡ʒˌiːˌe͡ɪbˈiː ˈe͡əd͡ʒɪk mˈɒdjʊlˌe͡ɪtəz], \dʒˌiːˌeɪbˈiː ˈeədʒɪk mˈɒdjʊlˌeɪtəz], \dʒ_ˌiː__ˌeɪ_b_ˈiː_ ˈeə_dʒ_ɪ_k m_ˈɒ_d_j_ʊ_l_ˌeɪ_t_ə_z]\
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Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. General anesthetics probably act at least partly by potentiating GABAergic responses, but they are not included here.
By DataStellar Co., Ltd
Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.